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a model system for in vitro studies of bank vole borne viruses银行田鼠的体外研究模型系统传播病毒
A Model System for In Vitro Studies of Bank Vole Borne
Viruses
1,2 ¨ 1,2 ˚ 3 4 2 5
Malin Stoltz *, Karin B. Sundstrom , Asa Hidmark , Conny Tolf , Sirkka Vene , Clas Ahlm , A. Michael
4 ˚ 1,6 ¨ 1,2
Lindberg , Ake Lundkvist , Jonas Klingstrom
1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, 2 Department of Preparedness, Swedish Institute for Communicable
Disease Control, Solna, Sweden, 3 Department of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg, Heidelberg, Germany, 4 School of
˚ ˚
Natural Sciences, Linnaeus University, Kalmar, Sweden, 5 Department of Clinical Microbiology, Infectious Diseases, Umea University, Umea, Sweden, 6 Department of
Epidemiology, Swedish Institute for Communicable Disease Control, Solna, Sweden
Abstract
The bank vole (Myodes glareolus) is a common small mammal in Europe and a natural host for several important emerging
zoonotic viruses, e.g. Puumala hantavirus (PUUV) that causes hemorrhagic fever with renal syndrome (HFRS). Hantaviruses
are known to interfere with several signaling pathways in infected human cells, and HFRS is considered an immune-
mediated disease. There is no in vitro-model available for infectious experiments in bank vole cells, nor tools for analyses of
bank vole immune activation and responses. Consequently, it is not known if there are any differences in the regulation of
virus induced responses in humans compared
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