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a conserved role for syndecan family members in the regulation of whole-body energy metabolism保存角色syndecan家人全身能量代谢的调节
A Conserved Role for Syndecan Family Members in the
Regulation of Whole-Body Energy Metabolism
1,2,3 4 1 1 5
Maria De Luca *, Yann C. Klimentidis , Krista Casazza , Michelle Moses Chambers , Ruth Cho ,
6 1 1 5 1,2,3
Susan T. Harbison , Patricia Jumbo-Lucioni , Shaoyan Zhang , Jeff Leips , Jose R. Fernandez
1 Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 2 Nutrition and Obesity Research Center,
University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 3 Diabetes Research Training Center, University of Alabama at Birmingham,
Birmingham, Alabama, United States of America, 4 Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham,
Alabama, United States of America, 5 Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland, United States of America,
6 Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America
Abstract
Syndecans are a family of type-I transmembrane proteins that are involved in cell-matrix adhesion, migration, neuronal
development, and inflammation. Previous quantitative genetic studies pinpointed Drosophila Syndecan (dSdc) as a
positional candidate gene affecting variation in fat storage between two Drosophila melanogaster strains. Here, we first used
quantitative complementation tests with dSdc mutants to confirm that natural variation in this gene affects variabil
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