有哪些信誉好的足球投注网站3d radiation therapy or intensity-modulated radiotherapy for recurrent and metastatic cervical cancer the shanghai cancer hospital experience三维放射治疗和调强放射治疗复发性和转移性宫颈癌上海肿瘤医院的经验.pdfVIP
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3d radiation therapy or intensity-modulated radiotherapy for recurrent and metastatic cervical cancer the shanghai cancer hospital experience三维放射治疗和调强放射治疗复发性和转移性宫颈癌上海肿瘤医院的经验
3D Radiation Therapy or Intensity-Modulated
Radiotherapy for Recurrent and Metastatic Cervical
Cancer: The Shanghai Cancer Hospital Experience
Su-Ping Liu, Xiao Huang*, Gui-Hao Ke, Xiao-Wei Huang
Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
Abstract
We evaluate the outcomes of irradiation by using three-dimensional radiation therapy (3D-RT) or intensity-modulated
radiotherapy (IMRT) for recurrent and metastatic cervical cancer. Between 2007 and 2010, 50 patients with recurrent and
metastatic cervical cancer were treated using 3D-RT or IMRT. The median time interval between the initial treatment and the
start of irradiation was 12 (6–51) months. Salvage surgery was performed before irradiation in 5 patients, and 38 patients
received concurrent chemotherapy. Sixteen patients underwent 3D-RT, and 34 patients received IMRT. Median follow-up for
all the patients was 18.3 months. Three-year overall survival and locoregional control were 56.1% and 59.7%, respectively.
Three-year progression-free survival and disease-free survival were 65.3% and 64.3%, respectively. Nine patients developed
grade 3 leukopenia. Grade 5 acute toxicity was not observed in any of the patients; however, 2 patients developed Grade 3
late toxicity. 3D-RT or IMRT is effective for the treatment of recurrent and metastatic cervical cancer, with the 3-year overall
survival of 56.1%, and its complications are acceptable. Long-term follow-up and further studies are needed to confirm the
role of 3D-RT or IMRT in the multimodality management of the disease.
Citation: Liu S-P, Huang X, Ke G-H, Huang X-W (2012) 3D Radiation Therapy or Intensity-Modulated Radiotherapy for Recurrent and Metastatic Cervical Cancer:
The Shanghai Cancer Hospital Experience. PLoS ONE 7(6): e40299. doi:10.1371/journal.pone.0040299
Editor: Apar Kishor Ganti, University of Nebraska Med
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