信号放大策略在电化学适体传感器中的应用进展-西南大学化学化工.pdfVIP

第34 卷第 3 期 学传感器 灾燥造援 34熏 晕燥援 3 圆 园 1 4 年 9 月 悦匀耘酝陨悦粤蕴 杂耘晕杂韵砸杂 Sept 援圆 园 1 4 信号放大策略在电化学适体传感器中的应用进展 丽娟 袁 若* 西南大学化学化工学院袁重庆400715冤 摘 要院 电化学适体传感器通过测定适体与目标物作用前后电化学信号的变化来实现对目标分析物的定 量检测 具有操作简单尧响应快速尧灵敏度高尧选择性好等优点遥 为进一步提高传感器的灵敏度 增强检测信 号成为研究者们在构建电化学适体传感器中常用的手段遥 通过纳米材料尧生物及化学等方法放大传感器界 面的响应信号 能特异性地提高检测信号 降低噪音信号 对于提高传感器的灵敏度具有十分重要的意义遥 该文简要介绍了电化学适体传感器的原理 重点评述了近十年来信号放大技术在电化学适体传感器方面的 研究和应用进展遥 关键词院 信号放大曰 电分析曰 适体曰 生物传感器曰 述 Proceedings of signal amplification strategies applied in electrochemical aptasensors Bai Li鄄j uan, Yuan Ruo* (College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China) Abstract: Electrochemical aptasensors used for quantitative detection of target analytes are based on the changes of electrochemical signals before and after the binding between aptamers and target analytes, which hold the advantages of simple operation, rapid response, high sensitivity and good selectivity. In order to further improve the sensitivity of the biosensor, enhance the detection signal become the common method for researchers in construction of electrochemical aptasensor. Using a variety of amplification technology such as nanomaterials, biological and chemical methods, could effectively enhance the detection signal and reduce the noise signal, which holds great significance in improvement the sensitivity of the aptasensor. The principle of electrochemical aptasensor is presented, and the proceedings of signal amplification strategies applied in electrochemical aptasensors during the last ten years