The Journal of Angioedemasit amet（《Angioedemasit amet）.pdf

  The Journal of Angioedemasit amet Brief Report: A Solemn Reminder of the Mortality Risk Associated With HAE 1 1 2 1 Sarita Patil, MD ; Autumn Guyer, MD ; Marc Riedl, MD, MS ; and Aleena Banerji, MD 1Department of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and 2Department of Clinical Immunology and Allergy, UCLA School of Medicine, Los Angeles, CA INTRODUCTION Hereditary angioedema (HAE), caused by congenital C1 Association (US HAEA) is limited, the data on HAE esterase inhibitor (C1-INH) deficiency, has long been lifespan are remarkably similar. recognized as a life-threatening condition. One of the Evidence of continued mortality from laryngeal edema earliest accounts of this condition describes asphyxiation even in diagnosed patients confirms the swift and in affected families.1 Individuals with HAE continue to be 2 potentially fatal nature of HAE attacks. Time of onset of described as “critically ill,” a description logically an acute laryngeal attack has been reported to be as generated by the natural history of HAE attacks in the short as 20 minutes in one child.4 Another recently absence of effective therapy. Over the past 3 decades, published study described 3 phases of fatal laryngeal tremendous adv