糖尿病病理和病理生理（Diabetic pathology and pathophysiology）.docVIP

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糖尿病病理和病理生理（Diabetic pathology and pathophysiology）.doc

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糖尿病病理和病理生理（Diabetic pathology and pathophysiology）

糖尿病病理和病理生理（Diabetic pathology and pathophysiology） Diabetes pathology and pathophysiology, your location: Medical Education Network clinical medicine theory Internal Medicine text hot topics: search course guidance book, diabetes pathology and pathophysiology 2008-10-27 11:45 [big and small] [I want error correction] [pathology] Type 1 diabetes mellitus The pathological changes of pancreatic islet are characterized by a marked decrease in the number of islet B cells and pancreatic inflammation. The course of disease is shorter than that in 1 years, and the number of B cells in the cases is only about 10% of normal. From 50% to 70% cases, there is islet inflammation, which is characterized by infiltration of lymphocytes and mononuclear cells in the islets of langerhans. Other changes include atrophy of the pancreas and vacuolar degeneration of B cells. In a small number of cases, there is no obvious pathological change in the islets. The number of cells secreting glucagon, somatostatin, and pancreatic polypeptide is normal or relatively increased. Type 2 diabetes islet pathological feature for amyloidosis, 90% patients with pancreatic islet in the light microscope the amyloid deposition in the capillaries and endocrine cells, the degree and extent of metabolic disturbance; in addition, the islet can have different degrees of fibrosis. The number of pancreatic islet B cells was moderate or not decreased, glucagon secretion cells increased, and the number of endocrine cells in other islets did not change significantly. The pathological changes of diabetic macrovascular diseases are atherosclerosis, middle and small atherosclerosis, which is basically the same as non diabetics. Diabetic microangiopathy is the lesion of capillary and microvascular network with lumen diameter between M and 100 and between arteriole and arteriole. Common in the retina, kidney, muscle, nerve, skin and other tissues, the characteristic lesions are PAS positive substances deposited in the