第四十章 大环内酯类、林可霉素类及多肽类抗生素（The fortieth chapter macrolide, lincomycins and polypeptide antibiotics）.docVIP

第四十章 大环内酯类、林可霉素类及多肽类抗生素（The fortieth chapter macrolide, lincomycins and polypeptide antibiotics） The fortieth chapter macrolide, lincomycins Polypeptide antibiotics Basic Requirements Key and difficult points Teaching hours Synopsis 1 basic requirements [TOP] 1.1 grasp the antibacterial, clinical and adverse reactions of erythromycin. 1.2 、 familiar with the antibacterial effects of lincomycin, clinical application and adverse reactions. 1.3 to understand the progress of erythromycin and the general situation of peptides. 2 key and difficult [TOP] 2.1 key The antibacterial action of erythromycin and its side effects were compared with that of penicillin. 2.2 difficulties Different dosage forms of erythromycin. 3 teaching hours [TOP] Recommendation 2 hours 4 abstracts [TOP], Section 1, verse second, verse third 4.1 section 1 macrolides antibiotics Macrolide (macrolides) is an antibiotic with 14, 15 and 16 macrolide rings. It is effective and without severe adverse reactions. It is commonly used as the first choice for aerobic G+, G- and anaerobic cocci, as well as alternatives to beta lactam antibiotics. The first generation of representative drugs, erythromycin, azithromycin, medicine is the representative of the second generation of roxithromycin and clarithromycin, third representative drug telithromycin and cethromycin. 4.1.1 classification Macrolide antibiotics are divided into chemical structures: 1.14 membered macrolides, including erythromycin (erythromycin), oleandomycin (oleandomycin), clarithromycin (clarithromycin), roxithromycin (roxithromycin), erythromycin (dirithromycin), telithromycin (telithromycin, telithromycin) and of erythromycin (cethromycin) etc.. 2.15 yuan macrolides, including azithromycin (azithromycin). 3.16 membered macrolides including Maddie kanamycin (Medecamycin) and acetyl Maddie (acetylmedecamycin), kanamycin (kitasamycin), kitasamycin acetylkitasamycin (acetylkitasamycin), josamycin (josamycin), spiramycin (spiramycin), Acetylspir