第三十八章 抗菌药物概论（The thirty-eighth chapter is introduction to antimicrobial agents）.docVIP

第三十八章 抗菌药物概论（The thirty-eighth chapter is introduction to antimicrobial agents） The thirty-eighth chapter is introduction to antimicrobial agents Basic Requirements Key and difficult points Teaching hours Synopsis 1 basic requirements [TOP] 1.1 master the common terms of antibacterial drugs, and the mechanism of action of antimicrobial agents. 1.2 familiar with principles of rational use of antibacterials. 2 key and difficult [TOP] 2.1 key Commonly used terms for antimicrobial agents; mechanisms of action of antimicrobial agents. 2.2 difficulties Bacterial resistance. 3 teaching hours [TOP] Recommendation 2 hours. 4 Summary Section 1 Introduction to antimicrobial agents Basic concepts of antimicrobial drugs 1. antibacterial drugs can inhibit or kill bacteria, used in the prevention and treatment of bacterial infections drugs. Antimicrobial agents include synthetic antibiotics (quinolones, etc.) and antibiotics. 2. antibiotics are metabolites of microorganisms (bacteria, fungi, and actinomycetes) with low molecular weight (5000), which can kill or inhibit other pathogenic microorganisms at low concentrations. Antibiotics consist of two groups: natural antibiotics and synthetic semisynthetic antibiotics. 3. antibacterial spectrum to inhibit or kill the range of pathogenic microorganisms. 4. antimicrobial agents inhibit or kill bacteria. It can be measured by two methods in vivo and in vitro. 5. drugs (bacteriostatic) is an antibacterial agent that can inhibit the growth and reproduction of bacteria without killing bacteria. 6. drugs (bactericidal) is not only to inhibit the growth and reproduction of bacteria, but also to kill bacteria antibacterial drugs, such as penicillins, cephalosporins, aminoglycosides and so on. 7. the minimum inhibitory concentration (MIC) were the lowest concentration of drug that can inhibit bacterial growth in culture. 8. the minimum bactericidal concentration (MBC) the lowest concentration of drug that can kill the bacteria culture mediu