癌的基因治疗的耐药性（Drug resistance in cancer gene therapy）.docVIP

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癌的基因治疗的耐药性（Drug resistance in cancer gene therapy）.doc

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癌的基因治疗的耐药性（Drug resistance in cancer gene therapy）

癌的基因治疗的耐药性（Drug resistance in cancer gene therapy） Glioma, anticancer, multidrug resistance gene therapy, principle analysis, theory Time: 2009-10-20 9:44:06 Author: this site edited 61 visits Why is tumor resection easy to relapse? Nanxun to present a new idea of malignant tumor recurrence and metastasis of malignant tumors: not only has the transfer mode, which is due to the presence of carcinogenic human local environment, will make the human stem cell gene mutation to form a value-added cells and tumor formation. As far as the present situation is concerned, the gene therapy of glioma is still in the experimental stage, and there are many practical problems. As the most used gene therapy vectors, applied to human existence of security problems, and how to choose a more secure, high selectivity to vector, vector transduction continues to increase in vivo, which need to explore; tumor suppressor gene p53, to inhibit the expression of MDR1 enhances tumor drug sensitivity because of good treatment in the future, become the focus of research in gene therapy of glioma; the development of new technologies, such as RNA interference because of specific gene silencing and was quickly applied to gene therapy related, and show a bright future. First, tumor suppressor gene therapy Proto oncogenes and tumor suppressor genes are all genes in normal cells. They play an important role in cell growth, division, differentiation and proliferation. The tumor suppressor gene, also known as an anti-cancer gene, is a class of genes found in normal cells that inhibit cell transformation and tumorigenesis. At present, more than 20 kinds of tumor suppressor genes have been isolated and cloned, and p53 gene is the highest tumor suppressor gene related to human tumors. Many studies have also proved that tumor formation is associated with the deletion of p53. In recent years, the study of p53 is also very popular. Gil2Perotin and other studies on the subventricular zone cells (SVC) in p53 de