王华产前筛查与质量控制（Wang Hua prenatal screening and quality control）.docVIP

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王华产前筛查与质量控制（Wang Hua prenatal screening and quality control）.doc

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王华产前筛查与质量控制（Wang Hua prenatal screening and quality control）

王华产前筛查与质量控制（Wang Hua prenatal screening and quality control） Prenatal screening and quality control Hunan maternal and child health care hospital Hunan prenatal diagnosis center Wang 0731-4332213 013873101825 Preface Prenatal screening and prenatal diagnosis: prevention of birth defects Important measures The role of Obstetrics, genetics, ultrasound physicians Definition of prenatal screening Prenatal screening refers to economical, simple and less trauma The detection method was found in pregnant women from certain groups High risk pregnant women with congenital defects and prenatal diagnosis Break to minimize the birth of an abnormal fetus. Prenatal screening standards Serious harm The incidence is higher and the population distribution is clear There is a definite method of diagnosis for screening positive The screening method is simple Screening costs were significantly lower than treatment costs Target diseases for prenatal screening and diagnosis Open neural tube defects (ONTD) Down syndrome (DS) Prenatal screening OTDS OTDS is caused by abnormal neural tube closure, without brain The incidence of spina bifida, spina bifida, and the incidence of About 2~6 per thousand Most of the fetus can not survive, even if the survival also exists Severe disability Etiology of OTDS It is related to folic acid and vitamin B deficiency in pregnant women Methylenetetrahydrofolate reductase (MTHFR) Mutation of 677C to T leads to decrease of enzyme activity AFP and ONTD screening AFP mainly in the fetal yolk sac, liver and gastrointestinal tract Synthesis。 The AFP in the amniotic fluid is mainly derived from fetal urine AFP in maternal serum is mainly transported through the placenta The transmission was derived from amniotic fluid, AFP, and fetal serum AFP AFP and ONTD screening Normally, maternal serum AFP is 16 weeks gestation Up to 25ng/ml, which has increased at a rate of 15% per week thereafter Add to pregnancy for 30 weeks. 30~32 weeks later, pregnant with Zhou Zeng Redu