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In Vivo Clearance and Toxicity of ...(体内间隙和毒性u2026)
A R T In Vivo Clearance and Toxicity of I Monodisperse Iron Oxide Nanocrystals C Luo Gu,† Ronnie H. Fang,) Michael J. Sailor,†,‡,§ and Ji-Ho Park^,* L † ) ‡ § E Department of Chemistry and Biochemistry, Department of Nanoengineering, Department of Bioengineering, and Materials Science and Engineering Program, University of California, San Diego, La Jolla, California 92093, United States, and ^Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Republic of Korea agnetic iron oxide (IO) nanoparti- cles are used in a range of biome- ABSTRACT Mdical applications: hyperthermia, magnetically targeted delivery, and particu- larly molecular magnetic resonance ima- ging (MRI) diagnosis.1,2 The superpara- magnetism of IO nanoparticles decreases the spinspin relaxation time of surround- ing water protons, enhancing the contrast in T2-weighted MR images.3 Several types of systemically administered IO nanoparticle contrast agents have been approved for human use by the U.S. Food and Drug Thermal decomposition of organometallic p
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