Formulat ion and evaluation of （Formulat离子和评价）.pdfVIP

Journal of Applied Pharmaceutical Science 01 (05); 20 11: 188- 190 ISSN: 2231-3354 Formulation and evaluation of Diphenhydramine Received: 11-05-2011 Revised on: 13-05-2011 Accepted: 16-05-2011 hydrochloride and Ibuprofen soft gelatin capsules Shyamala Bhaskaran, Pradeep GC and Lakshmi PK ABSTRACT The present invention provides a new composition for treating pain-associated sleep disturbances, especially shortened sleep duration, comprising ibuprofen and diphenhydramine Shyamala Bhaskaran hydrochloride. In the present work the soft gelatin capsules were formulated comprising 25 mg Department of Pharmaceutics diphenhydramine hydrochloride and 200 mg ibuprofen using polyethylene glycol 400, propylene Agnihotri College of Pharmacy glycol, potassium hydroxide and purified water. The prepared soft gelatin capsules were evaluated Wardha, India. for weight variation test, assay, dissolution and disintegration. The capsules had a fill weight of 550 ± 5%, Disintegration time of 5-6 minutes and showed 97.00% to 99.50% of labeled amount of ibuprofen and diphenhydramine hydrochloride indicating uniformity in drug contents. The Pradeep. GC capsules containing 75 mg/capsule of propylene glycol released 99.40% of diphenhydramine Departmant of Pharmacuetics, hydrochloride a