nasal bone shape is under complex epistatic genetic control in mouse interspecific recombinant congenic strains鼻骨形状复杂的上位性遗传控制鼠标种间句重组菌株.pdfVIP

Nasal Bone Shape Is under Complex Epistatic Genetic Control in Mouse Interspecific Recombinant Congenic Strains ´ 1,2,3 4 2 1 Gaetan Burgio *, Michel Baylac , Evelyne Heyer , Xavier Montagutelli ´ ´ ´ ´ 1 Institut Pasteur, Unite de Genetique Fonctionnelle de la Souris, Centre National de la Recherche Scientifique, URA 2578, Paris, France, 2 Unite d’Eco-Anthropologie, ´ ´ ´ ´ equipe, Genetique des Populations Humaines, Centre National de la Recherche Scientifique, Museum National d’Histoire Naturelle, Universite Paris 7, UMR 7206, Paris, ´ France, 3 Department of Genetics, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia, 4 Organisation, Structure et Evolution de la Biodiversite ´ ´ UMR 5202 et Plateforme de Morphometrie, Centre National de la Recherche Scientifique IFR 101 et UMR 5202, Laboratoire d’Entomologie du Museum National d’Histoire Naturelle, Paris, France Abstract Background: Genetic determinism of cranial morphology in the mouse is still largely unknown, despite the localization of putative QTLs and the identification of genes associated with Mendelian skull malformations. To approach the dissection of this multigenic control, we have used a set of inters