有哪些信誉好的足球投注网站mutations in escherichia coli acee and ribb genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathway基因突变在大肠杆菌美国和瑞柏允许生存的菌株有缺陷的类异戊二烯生物合成途径的第一步.pdfVIP
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mutations in escherichia coli acee and ribb genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathway基因突变在大肠杆菌美国和瑞柏允许生存的菌株有缺陷的类异戊二烯生物合成途径的第一步
Mutations in Escherichia coli aceE and ribB Genes Allow Survival of Strains Defective in the First Step of the Isoprenoid Biosynthesis Pathway 1 1 ¨ 1¤ 1 2 Jordi Perez-Gil , Eva Maria Uros , Susanna Sauret-Gueto , L. Maria Lois , James Kirby , 2 2 2 1,3 Minobu Nishimoto , Edward E. K. Baidoo , Jay D. Keasling , Albert Boronat , Manuel Rodriguez- Concepcion1* 1 Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Campus UAB Bellaterra, Barcelona, Spain, 2 Joint BioEnergy Institute, Emeryville, California, ´ United States of America, 3 Department de Bioquımica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain Abstract A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria. In the first two steps of the pathway, MEP is produced from the central metabolic intermediates pyruvate and glyceraldehyde 3-phosphate via 1-deoxy-D-xylulose 5-phosphate (DXP) by the activity of the enzymes DXP synthase (DXS) and DXP reductoisomerase (DXR). Because the MEP pathway is absent from humans, it was proposed as a promising new target to develop new antibiotics. However, the lethal phenotype caused by the deletion of DXS or DXR was found to be suppressed with a relatively high efficiency by unidentified mutations. Here we report that several mutations in the unrelated genes aceE and ribB rescue growth of DXS-defective mutants because the encoded enzymes allowed the production
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