有哪些信誉好的足球投注网站molecular immune responses to aerosol challenge with francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy分子免疫反应与土拉杆菌内气溶胶挑战小鼠接种活疫苗候选人不同的功效.pdfVIP
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molecular immune responses to aerosol challenge with francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy分子免疫反应与土拉杆菌内气溶胶挑战小鼠接种活疫苗候选人不同的功效
Molecular Immune Responses to Aerosol Challenge with Francisella tularensis in Mice Inoculated with Live Vaccine Candidates of Varying Efficacy 1 1 1 2 3 1 Hua Shen , Gregory Harris , Wangxue Chen , Anders Sjostedt , Patrik Ryden , Wayne Conlan * ˚ 1 Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada, 2 Department of Clinical Microbiology, Clinical Bacteriology, Umea ˚ ˚ University, Umea, Sweden, 3 Department of Mathematics and Mathematical Statistics, Department of Statistics, Computational Life Science Cluster, Umea University, ˚ Umea, Sweden Abstract Background: Francisella tularensis is a facultative intracellular bacterial pathogen and the etiological agent of tularemia. The subspecies F. tularensis tularensis is especially virulent for humans when inhaled and respiratory tularemia is associated with high mortality if not promptly treated. A live vaccine strain (LVS) derived from the less virulent holarctica subspecies confers incomplete protection against aerosol challenge with subsp. tularensis. Moreover, correlates of protection have not been established for LVS. Methodology/Principal Findings: In the present study we compare molecular immune responses elicited by LVS and two defined deletion mutants of clinical subsp. tularensis strain, SCHU S4, that confer enhanced protection in a mouse model. BALB/c mice were immunized intradermally then challenge
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