htlv-1 and hiv-2 infection are associated with increased mortality in a rural west african communityhtlv 1和hiv - 2感染与死亡率增加有关农村社区西非.pdfVIP

HTLV-1 and HIV-2 Infection Are Associated with Increased Mortality in a Rural West African Community 1 2 1 1 ¨ Carla van Tienen , Maarten Schim van der Loeff *, Ingrid Peterson , Matthew Cotten , Soren 3 4 1 1,5 6 7 Andersson , Birgitta Holmgren , Tim Vincent , Thushan de Silva , Sarah Rowland-Jones , Peter Aaby , Hilton Whittle1 1 Medical Research Council, Fajara, The Gambia, 2 Municipal Health Service and Academic Medical Centre, Amsterdam, The Netherlands, 3 Swedish Institute of Infectious ¨ Disease Control, Stockholm, Sweden, 4 Department of Laboratory Medicine, Malmo, Lund University, Lund, Sweden, 5 University College London Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom, 6 Weatherall Institute of Molecular Medicine, Human ´ Immunology Unit, John Radcliffe Hospital, Oxford, United Kingdom, 7 Projecto de Saude de Bandim, Indepth Network, Bissau, Guinea-Bissau Abstract Background: Survival of people with HIV-2 and HTLV-1 infection is better than that of HIV-1 infected people, but long-term follow-up data are rare. We compared mortality rates of HIV-1, HIV-2, and HTLV-1 infected subjects with those of retrovirus- uninfected people in a rural community in Guinea-Bissau. Methods: In 1990, 1997 and 2007, adult residents (aged $15 years) were interviewed, a blood sample was drawn and retroviral s