有哪些信誉好的足球投注网站host heterogeneous ribonucleoprotein k (hnrnp k) as a potential target to suppress hepatitis b virus replication主机异构核糖核蛋白k(hnrnp k)作为一个潜在的目标抑制乙型肝炎病毒复制.pdfVIP
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host heterogeneous ribonucleoprotein k (hnrnp k) as a potential target to suppress hepatitis b virus replication主机异构核糖核蛋白k(hnrnp k)作为一个潜在的目标抑制乙型肝炎病毒复制
Open access, freely available online PLoS MEDICINE Host Heterogeneous Ribonucleoprotein K (hnRNP K) as a Potential Target to Suppress Hepatitis B Virus Replication 1 2 2 1 1 3 Lisa F. P. Ng , Marieta Chan , Soh-Ha Chan , Paul Chung-Pui Cheng , Eastwood Hon-Chiu Leung , Wei-Ning Chen , Ee-Chee Ren1,2* 1 Genome Institute of Singapore, Singapore, 2 Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore, 3 School of Biological Sciences, Nanyang Technological University, Singapore Competing Interests: The authors A B S T R A C T have declared that no competing interests exist. Background Author Contributions: LFPN, MC, SHC, WNC, and ECR designed the Hepatitis B virus (HBV) infection results in complications such as cirrhosis and hepatocellular study. LFPN, MC, PCPC, EHCL, and carcinoma. Suppressing viral replication in chronic HBV carriers is an effective approach to WNC performed the experiments. controlling disease progression. Although antiviral compounds are available, we aimed to LFPN, MC, and ECR contributed to writing the paper. identify host factors that have a significant effect on viral replication efficiency. Academic Editor: Paul D. Griffiths, Royal Free and University College Methods and Findings Medical School, United Kingdom We studied a group of hepatitis B carriers by associating serum viral load with their Citation: Ng LFP, Chan M, Chan SH, respective HBV genomes, and observed a significant association between h
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