habitual physical activity in mitochondrial disease习惯性的身体活动在线粒体疾病.pdfVIP

Habitual Physical Activity in Mitochondrial Disease 1. 1,2,3. 3 1 ¨ 4 Shehnaz Apabhai , Grainne S. Gorman , Laura Sutton , Joanna L. Elson , Thomas Plotz , Douglass M. Turnbull1,2,3, Michael I. Trenell1,2,3* 1 Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, United Kingdom,, 2 NIHR Biomedical Research Centre for Ageing and Age-related Disease, Newcastle University, Newcastle upon Tyne, United Kingdom, 3 Newcastle Centre for Brain Ageing and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom, 4 School of Computing, Newcastle University, Newcastle upon Tyne, United Kingdom Abstract Purpose: Mitochondrial disease is the most common neuromuscular disease and has a profound impact upon daily life, disease and longevity. Exercise therapy has been shown to improve mitochondrial function in patients with mitochondrial disease. However, no information exists about the level of habitual physical activity of people with mitochondrial disease and its relationship with clinical phenotype. Methods: Habitual physical activity, genotype and clinical presentations were assessed in 100 patients with mitochondrial disease. Comparisons were made with a control group individually matched by age, gender and BMI. Results: Patients with mitochondrial disease had significantly lower levels of physical activity in comparison to matched people without mitochondrial disease (steps/day; 688363944 vs. 992464088, p = 0.001). 78% of the mitochondrial disease cohort did not achieve 10,000 steps per day and 48%were classified as overweight or obese. Mitochondrial disease was associated with less breaks in sedentary activity (Sedentary to Active Transitions, % per day; 13 60.03 vs.