gata-4 and fog-2 expression in pediatric ovarian sex cord-stromal tumors replicates embryonal gonadal phenotype results from the trep projectgata-4和fog-2表达在小儿卵巢性cord-stromal肿瘤复制胚胎性腺的表型结果trep项目.pdfVIP

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gata-4 and fog-2 expression in pediatric ovarian sex cord-stromal tumors replicates embryonal gonadal phenotype results from the trep projectgata-4和fog-2表达在小儿卵巢性cord-stromal肿瘤复制胚胎性腺的表型结果trep项目.pdf

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gata-4 and fog-2 expression in pediatric ovarian sex cord-stromal tumors replicates embryonal gonadal phenotype results from the trep projectgata-4和fog-2表达在小儿卵巢性cord-stromal肿瘤复制胚胎性腺的表型结果trep项目

GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype: Results from the TREP Project 1 1 2 3 4 Calogero Virgone *, Giovanni Cecchetto , Andrea Ferrari , Gianni Bisogno , Vittoria Donofrio , 5 6 1 7 Renata Boldrini , Paola Collini , Patrizia Dall’Igna , Rita Alaggio 1 Pediatric Surgery, Departments of Pediatrics and Gynaecology-Obstetrics, University Hospital, Padua, Italy, 2 Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy, 3 Hematology Oncology, Departments of Pediatrics and Gynaecology-Obstetrics, University Hospital, Padua, Italy, 4 Servizio di Anatomia e Istologia Patologica, ` Azienda Ospedaliera di Rilievo Nazionale ‘‘Santobono Pausillipon’’, Naples, Italy, 5 Pathology Unit, ‘‘Bambino Gesu’’ Pediatric Hospital, Rome, Italy, 6 Pathology Unit, Istituto Nazionale Tumori, Milan, Italy, 7 Pathology Unit, Department of Medical and Diagnostic Sciences and Special Therapies, University of Padua, Padua, Italy Abstract Aim: GATA proteins are a family of zinc finger transcription factors regulating gene expression, differentiation and proliferation in various tissues. The expression of GATA-4 and FOG-2, one of its modulators, was studied in pediatric Sex Cord-Stromal tumors of the ovary, in order to evaluate their potential role as diagnostic markers and prognostic factors. Materials and Methods: Clinical and histological data of 15 patients, enrolled into the TREP Project since 2000 were evaluated. When available,