focal retrograde amnesia voxel-based morphometry findings in a case without mri lesions焦逆行性遗忘分布形态测量学发现在一个没有mri病灶的情况.pdfVIP

Focal Retrograde Amnesia: Voxel-Based Morphometry Findings in a Case without MRI Lesions 1,2 1,2 ¨ 1 2 1,2 Bernhard Sehm *, Stefan Frisch , Angelika Thone-Otto , Annette Horstmann , Arno Villringer , Hellmuth Obrig1,2 1 Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany, 2 Department for Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Abstract Focal retrograde amnesia (FRA) is a rare neurocognitive disorder presenting with an isolated loss of retrograde memory. In the absence of detectable brain lesions, a differentiation of FRA from psychogenic causes is difficult. Here we report a case study of persisting FRA after an epileptic seizure. A thorough neuropsychological assessment confirmed severe retrograde memory deficits while anterograde memory abilities were completely normal. Neurological and psychiatric examination were unremarkable and high-resolution MRI showed no neuroradiologically apparent lesion. However, voxel-based morphometry (VBM)-comparing the MRI to an education-, age-and sex-matched control group (n = 20) disclosed distinct gray matter decreases in left temporopolar cortex and a region between right posterior parahippocampal and lingual cortex. Although the results of VBM-based comparisons between a single case and a healthy control group are generally susceptible to differences unrelated to the specific symptoms of the case, we believe that our data suggest a causal role of the cortical areas detected since the retrograde memory deficit is the preeminent neuropsychological difference between patient and controls. This was p