gata2 is associated with familial early-onset coronary artery diseasegata2与家族早发性冠状动脉疾病.pdfVIP

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gata2 is associated with familial early-onset coronary artery diseasegata2与家族早发性冠状动脉疾病.pdf

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gata2 is associated with familial early-onset coronary artery diseasegata2与家族早发性冠状动脉疾病

GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease 1 1 1 1 1 1,2 1 Jessica J. Connelly , Tianyuan Wang , Julie E. Cox , Carol Haynes , Liyong Wang , Svati H. Shah , David R. Crosslin , 1 1 3 1 4 5 A. Brent Hale , Sarah Nelson , David C. Crossman , Christopher B. Granger , Jonathan L. Haines , Christopher J. H. Jones , 1 6 2 1 1* Jeffery M. Vance , Pascal J. Goldschmidt-Clermont , William E. Kraus , Elizabeth R. Hauser , Simon G. Gregory 1 Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States, 2 Department of Medicine and Division of Cardiology, Duke University Medical Center, Durham, North Carolina, United States, 3 Cardiovascular Research Group, Northern General Hospital, University of Sheffield, Sheffield, United Kingdom, 4 Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States, 5 University of Wales College of Medicine, Cardiff, United Kingdom, 6 Miller School of Medicine, University of Miami, Miami, Florida, United States The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the aortic vasculature, namely aortic endothelial cells and smooth muscle cells. We have shown that GATA2 expression is predictive of location within the thoracic aorta; location is sugges