folliculin, the product of the birt-hogg-dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion经酮,birt-hogg-dube肿瘤抑制基因的产物,与adherens结蛋白p0071监管信息附着力.pdfVIP

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folliculin, the product of the birt-hogg-dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion经酮,birt-hogg-dube肿瘤抑制基因的产物,与adherens结蛋白p0071监管信息附着力.pdf

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folliculin, the product of the birt-hogg-dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion经酮,birt-hogg-dube肿瘤抑制基因的产物,与adherens结蛋白p0071监管信息附着力

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion 1. 1. 2 3 Doug A. Medvetz , Damir Khabibullin , Venkatesh Hariharan , Pat P. Ongusaha , 4 5 6 5 4 Elena A. Goncharova , Tanja Schlechter , Thomas N. Darling , Ilse Hofmann , Vera P. Krymskaya , 3 2 1 James K. Liao , Hayden Huang , Elizabeth P. Henske * 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 2 Department of Biomedical Engineering, Columbia University, New York, New York, United States of America, 3 Vascular Medicine Research Unit, Brigham Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 4 Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 5 Joint Research Division Vascular Biology, Medical Faculty Mannheim and German Cancer Research Center (DKFZ-ZMBH-Alliance), Mannheim, Germany, 6 Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America Abstract Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to elucidate the pathogenesis of BHD, we discovered a physical interaction between folliculin (FLCN),