基因检测在脑血管病精准医疗中的应用.pdfVIP

中国现代神经疾病杂志 年 月第 卷第 期 7 ·500 · 2017 7 17 7 Chin J Contemp Neurol Neurosurg, July 2017, Vol. 17, No. 专题综述 · · 基因检测在脑血管病精准医疗中的应用 折潇 邓艳春 【摘要】 精准医疗是以个体化医疗为基础、随着基因检测技术快速进步以及生物学信息和大数据 科学交叉应用而发展起来的新型医学概念与医疗模式。基因检测技术是精准医疗的基础。脑血管病是 遗传因素和环境因素相互作用的多因素疾病，其中遗传因素发挥重要作用。本文拟从单基因遗传病、基 因多态性、药物遗传学研究和精准治疗等方面阐述基因检测在脑血管病精准医疗中的应用。 【关键词】 脑血管障碍； 基因； 综述 Applicationofgenedetectioninprecisionmedicineofcerebrovasculardisease 1 2 ZHE Xiao , DENG Yan⁃chun 1Department of Neurology, the First Affiliated Hospital of Xian Medical University, Xian 710077, Shaanxi, China 2Department of Neurology, Xijing Hospital, the Fourth Military Medical University of Chinese PLA, Xian 710032, Shaanxi, China Corresponding author: DENG Yan chun (Email: yanchund@fmmu.edu.cn) ⁃ 【 】 Abstract Precision medicine (PM), a new type of medical concept and model which based on personalized medicine, is developed with the fast progress of genetic detection technology and the cross ⁃ application of biological information and large data science. Genetic detection technology is the basis of PM. Cerebrovascular disease is a multifactorial disease, in which genetic factors play an important role in the pathogenesis. This paper intends to discuss the application of gene detection technology in the PM of cerebrovascular disease, including single gene genetic disease, genetic polymorphism, drug genetics research and precision treatment. 【 】 Keywords Cerebrovascular disorders; Genes; Review This study was su