a1c as a diagnostic criteria for diabetes in low- and middle-income settings evidence from peru糖化血红蛋白作为糖尿病诊断标准在低收入和中等收入设置来自秘鲁的证据.pdfVIP

A1C as a Diagnostic Criteria for Diabetes in Low- and Middle-Income Settings: Evidence from Peru 1,2,3 1,4 1 1,2 J. Jaime Miranda *, Antonio Bernabe-Ortiz , Sanja Stanojevic , German Malaga , Robert H. Gilman1,5,6, Liam Smeeth1,3 1 CRONICAS – Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru, 2 Department of Medicine, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru, 3 Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, 4 Epidemiology Unit, School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru, 5 Department of International Health, Johns Hopkins Bloomberg School ´ ´ of Public Health, Baltimore, Maryland, United States of America, 6 Area de Investigacion y Desarrollo, A. B. PRISMA, Lima, Peru Abstract Objectives: To determine the prevalence of type 2 diabetes mellitus, in three groups of Peruvian adults, using fasting glucose and glycosylated hemoglobin (A1C). Methodology/Principal Findings: This study included adults from the PERU MIGRANT Study who had fasted $8 h. Fasting glucose $126 mg/dL and A1C$6.5% were used, separately, to define diabetes. Subjects with a current diagnosis of diabetes were excluded. 964 of 988 subjects were included in this analysis. Overall, 0.9% (95%CI 0.3–1.5) and 3.5% (95%CI 2.4–4.7) had diabetes using fasting glucose and A1C criteria, respectively. Compared to those classified as having diabetes using fasting glucose, newly classified subjects with diabetes usi