a synthetic uric acid analog accelerates cutaneous wound healing in mice尿酸合成模拟加速皮肤伤口愈合的老鼠.pdfVIP

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a synthetic uric acid analog accelerates cutaneous wound healing in mice尿酸合成模拟加速皮肤伤口愈合的老鼠.pdf

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a synthetic uric acid analog accelerates cutaneous wound healing in mice尿酸合成模拟加速皮肤伤口愈合的老鼠

A Synthetic Uric Acid Analog Accelerates Cutaneous Wound Healing in Mice 1,2,3. 1. 3 1 Srinivasulu Chigurupati , Mohamed R. Mughal , Sic L. Chan , Thiruma V. Arumugam , Akanksha 3 1 1 1 4 2 Baharani , Sung-Chun Tang , Qian-Sheng Yu , Harold W. Holloway , Ross Wheeler , Suresh Poosala , Nigel H. Greig1, Mark P. Mattson1,5* 1 Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, 2 Research Resources Branch, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America, 3 Biomolecular Science, University of Central Florida, Orlando, Florida, United States of America, 4 Department of Pathology and Medical Education, University of Central Florida, Orlando, Florida, United States of America, 5 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Abstract Wound healing is a complex process involving intrinsic dermal and epidermal cells, and infiltrating macrophages and leukocytes. Excessive oxidative stress and associated inflammatory processes can impair wound healing, and antioxidants have been reported to improve wound healing in animal models and human subjects. Uric acid (UA) is an efficient free radical scavenger, but has a very low solubility and poor tissue penetrability. We recently developed novel UA analogs with increased solubility and excellent free radical-scavenging properties and demonstrated their ability to protect neural cells against oxidative damage. Here we show that the ur