a randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy蒿甲醚的随机对照试验苯芴醇为无并发症恶性疟原虫对青蒿琥酯治疗怀孕.pdfVIP

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a randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy蒿甲醚的随机对照试验苯芴醇为无并发症恶性疟原虫对青蒿琥酯治疗怀孕.pdf

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a randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy蒿甲醚的随机对照试验苯芴醇为无并发症恶性疟原虫对青蒿琥酯治疗怀孕

PLoS MEDICINE A Randomised Controlled Trial of Artemether-Lumefantrine Versus Artesunate for Uncomplicated Plasmodium falciparum Treatment in Pregnancy 1,2,3* 1 1,2,3 1 1 Rose McGready , Saw Oo Tan , Elizabeth A. Ashley , Mupawjay Pimanpanarak , Jacher Viladpai-nguen , Lucy Phaiphun1 ¨ 1 1,2 1 1 2,3 , Katja Wustefeld , Marion Barends , Natthapon Laochan , Lily Keereecharoen , Niklas Lindegardh , Pratap Singhasivanon2, Nicholas J. White2,3, Franc¸ois Nosten1,2,3 1 Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand, 2 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 3 Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom Funding: This study received A B S T R A C T financial support from the UNDP/ World Bank/WHO Special Programme for Research and Training in Tropical Medicine (TDR), Grant ID A41150 and Background was part of the Wellcome Trust Mahidol University Oxford Tropical To date no comparative trials have been done, to our knowledge, of fixed-dose artemisinin Medicine Research Programme combination therapies (ACTs) for the treatment of Plasmodium falciparum malaria in funded by the Wellcome Trust of Great Britain. The funders had no role pregnancy. Evidence on the safety and efficacy of ACTs in pregnancy is needed as these in study design, data collection and drugs are being used i