a neurotoxic phosphoform of elk-1 associates with inclusions from multiple neurodegenerative diseases的神经毒性phosphoform elk-1 associates夹杂物与多种神经退行性疾病.pdfVIP

A Neurotoxic Phosphoform of Elk-1 Associates with Inclusions from Multiple Neurodegenerative Diseases 1. 2. 3. 3 4 5 Anup Sharma , Linda M. Callahan , Jai-Yoon Sul , Tae Kyung Kim , Lindy Barrett , Minsun Kim , 2 6 1,3,7 James M. Powers , Howard Federoff , James Eberwine * 1 Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 2 Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America, 3 Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 4 Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, 5 Department of Physiology, Wonkwang University School of Medicine, Iksan, South Korea, 6 Department of Neurology, Georgetown University Medical Center, Washington, D.C., United States of America, 7 Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Abstract Neurodegenerative diseases are characterized by a number of features including the formation of inclusions, early synaptic degeneration and the selective loss of neurons. Molecules serving as links between these shared features have yet to be identified. Identifying candidates within the diseased microenvironment will open up novel avenues for therapeutic intervention. The transcription factor Elk-1 resides within multiple brain areas both in nuclear and extranuclear neuronal compartments. Int