有哪些信誉好的足球投注网站a method for similarity search of genomic positional expression using cage基因的相似性有哪些信誉好的足球投注网站方法使用笼位置表达式.pdfVIP
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a method for similarity search of genomic positional expression using cage基因的相似性有哪些信誉好的足球投注网站方法使用笼位置表达式
A Method for Similarity Search of Genomic
Positional Expression Using CAGE
1 1 2 2,3 2,3 2,3
Shigeto Seno , Yoichi Takenaka , Chikatoshi Kai , Jun Kawai , Piero Carninci , Yoshihide Hayashizaki ,
1*
Hideo Matsuda
1 Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Osaka, Japan, 2 Genome Exploration Research Group
(Genome Network Project Core Group), RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan, 3 Genome Science Laboratory, Discovery Research
Institute, RIKEN Wako Institute, Wako, Japan
With the advancement of genome research, it is becoming clear that genes are not distributed on the genome in
random order. Clusters of genes distributed at localized genome positions have been reported in several eukaryotes.
Various correlations have been observed between the expressions of genes in adjacent or nearby positions along the
chromosomes depending on tissue type and developmental stage. Moreover, in several cases, their transcripts, which
control epigenetic transcription via processes such as transcriptional interference and genomic imprinting, occur in
clusters. It is reasonable that genomic regions that have similar mechanisms show similar expression patterns and that
the characteristics of expression in the same genomic regions differ depending on tissue type and developmental
stage. In this study, we analyzed gene expression patterns using the cap analysis gene expression (CAGE) method for
exploring systematic views of the mouse transcriptome. Counting the number of mapped CAGE tags for fixed-length
regions allowed us to determine genomic expression levels. These expression levels were normalized, quantified, and
converted into four t
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