有哪些信誉好的足球投注网站a lentivirus-mediated genetic screen identifies dihydrofolate reductase (dhfr) as a modulator of β-cateningsk3 signalinglentivirus-mediated遗传屏幕识别二氢叶酸还原酶(dhfr)作为β-cateningsk3信号调制器.pdfVIP
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a lentivirus-mediated genetic screen identifies dihydrofolate reductase (dhfr) as a modulator of β-cateningsk3 signalinglentivirus-mediated遗传屏幕识别二氢叶酸还原酶(dhfr)作为β-cateningsk3信号调制器
A Lentivirus-Mediated Genetic Screen Identifies Dihydrofolate Reductase (DHFR) as a Modulator of b- Catenin/GSK3 Signaling 1 1 1 2 1 Richard A. Klinghoffer *, Jason Frazier , James Annis , Jason D. Berndt , Brian S. Roberts , William T. 1 3 4 3 2 1 Arthur , Raul Lacson , Xiaohua Douglas Zhang , Marc Ferrer , Randall T. Moon , Michele A. Cleary 1 Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America, 2 Howard Hughes Medical Institute, Institute for Stem Cell and Regenerative Medicine, and Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington, United States of America, 3 Department of Automated Biotechnology, Merck Research Laboratories, Merck Co., Inc., North Wales, Pennsylvania, United States of America, 4 Department of Biometrics Research, Merck Research Laboratories, Merck Co., Inc., West Point, Pennsylvania, United States of America Abstract The multi-protein b-catenin destruction complex tightly regulates b-catenin protein levels by shuttling b-catenin to the proteasome. Glycogen synthase kinase 3b (GSK3b), a key serine/threonine kinase in the destruction complex, is responsible for several phosphorylation events that mark b-catenin for ubiquitination and subsequent degradation. Because modulation of both b-catenin and GSK3b activity may have important implications for treating disease, a complete understanding of the mechanisms that regulate the b-catenin/GSK3b interaction is warranted. We screened an arrayed lentivirus library expressing small hairpin RNAs (shRNAs) targeting 5,201 human druggable genes
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