a 10-year analysis of the effects of media coverage of regulatory warnings on antidepressant use in the netherlands and uk10年的媒体报道的影响分析监管警告在荷兰和英国使用抗抑郁药.pdfVIP

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a 10-year analysis of the effects of media coverage of regulatory warnings on antidepressant use in the netherlands and uk10年的媒体报道的影响分析监管警告在荷兰和英国使用抗抑郁药.pdf

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a 10-year analysis of the effects of media coverage of regulatory warnings on antidepressant use in the netherlands and uk10年的媒体报道的影响分析监管警告在荷兰和英国使用抗抑郁药

A 10-Year Analysis of the Effects of Media Coverage of Regulatory Warnings on Antidepressant Use in The Netherlands and UK 1 1 2 Juan Francisco Hernandez , Aukje K. Mantel-Teeuwisse , Ghislaine J. M. W. van Thiel , 1 3 4 1,5 1,6 Svetlana V. Belitser , Jan Warmerdam , Vincent de Valk , Jan A. M. Raaijmakers , Toine Pieters * 1 Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands, 2 Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands, 3 IMS Health, Capelle aan den IJssel, The Netherlands, 4 Genees-en hulpmiddelen Informatie Project (GIP – Drug Information Project), Healthcare Insurance Board (CVZ), Diemen, The Netherlands, 5 GlaxoSmithKline, External Scientific Collaborations Europe, Zeist, The Netherlands, 6 EMGO, VU Medical Centre, Amsterdam, The Netherlands Abstract Background: In 2003–2004 and 2007–2008, the regulatory banning of SSRI use in pediatrics and young adults due to concerns regarding suicidality risk coincided with negative media coverage. SSRI use trends were analyzed from 2000–2010 in the Netherlands (NL) and the UK, and whether trend changes might be associated with media coverage of regulatory warnings. Methods: Monthly SSRIs sales were presented as DDDs/1000 inhabitants/day. SSRI-use trends were studied using time- series segmented regression analyses. Timing of trend changes was compared with two periods of media coverage of warning