a biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat两相的和大脑区域选择性下调环磷酸腺苷浓度支持对象识别的老鼠.pdfVIP

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a biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat两相的和大脑区域选择性下调环磷酸腺苷浓度支持对象识别的老鼠.pdf

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a biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat两相的和大脑区域选择性下调环磷酸腺苷浓度支持对象识别的老鼠

A Biphasic and Brain-Region Selective Down-Regulation of Cyclic Adenosine Monophosphate Concentrations Supports Object Recognition in the Rat ¨ 1,2 1 1 1 ¨ 1,3 Maıte Hotte , Franc¸ois Dauphin , Thomas Freret , Michel Boulouard , Guenaelle Levallet * ´ ´ ´ ´ 1 Universite de Caen Basse–Normandie, Groupe Memoire et Plasticite comportementale (GMPc), EA4259, IFR 146, Caen, France, 2 Universite de Rouen, NeoVasc, EA 4309, IFRMP23, IHURBM, Rouen, France, 3 CHU de Caen, Service d’Anatomie Pathologie, Caen, France Abstract Background: We aimed to further understand the relationship between cAMP concentration and mnesic performance. Methods and Findings: Rats were injected with milrinone (PDE3 inhibitor, 0.3 mg/kg, i.p.), rolipram (PDE4 inhibitor, 0.3 mg/ kg, i.p.) and/or the selective 5-HT4R agonist RS 67333 (1 mg/kg, i.p.) before testing in the object recognition paradigm. Cyclic AMP concentrations were measured in brain structures linked to episodic-like memory (i.e. hippocampus, prefrontal and perirhinal cortices) before or after either the sample or the testing phase. Except in the hippocampus of rolipram treated-rats, all treatment increased cAMP levels in each brain sub-region studied before the sample phase. After the sample phase, cAMP levels were significantly increased in hippocampus (1.8 fold), prefrontal (1.3 fold) and perirhinal (1.3 fold) cortices from controls rat while decreased in prefrontal cortex (,0.83 to 0.62 fold) from drug-treated rats (except for milrinone+RS 67333 treatment). After the testing phase, cAMP con