型糖尿病患者颈动脉粥样硬化与代谢因素的关系谭姣容田冬梅童平.DOC

2型糖尿病患者颈动脉粥样硬化与代谢因素的关系 谭姣容 田冬梅 童平 杨昕 张立娟 王芳 基金项目：国家自然基金（项目编号上海市卫生局局级科研项目田冬梅，E-mail：tian_zili@ 0.05。3.多元Logistic回归分析显示：年龄、HbA1c与LDL-c是IMT的独立危险因素,OR值分别为1.075、1.123、2.125，P0.05。结论 在2型糖尿病患者中，年龄、血压、血糖、血脂与颈动脉粥样硬化的发生密切相关。对于2型糖尿病患者，控制血压、血糖、血脂对于预防及延缓颈动脉粥样硬化的发生十分重要。 【关键词】2型糖尿病；颈动脉粥样硬化；颈动脉内中膜厚度；代谢因素。 Relationship between metabolic factors and carotid atherosclerosis of type 2 diabetes 【Abstract】 Objective To research the elationship between metabolic factors and carotid atherosclerosis of type 2 diabetes (T2DM). Methods 456 outpatients with type 2 diabetes were recruited in Shanghai Putuo District People’s hospital and their age, height, weight, blood pressure, lipids, HbA1c, Intima-media thickness (IMT) were acquired to analyze the risk factors that related to carotid atherosclerosis in type 2 diabetes (T2DM). Results 1.Of 456 diabetic subjects，were categorized to carotid atherosclerosis,242 were non-atherosclerosis（control group）. The age, Systolic blood pressure，Diastolic blood pressure, HbA1c, TC, LDL-c of atherosclerosis patients were significantly different with control group. 2. Age, Systolic blood pressure，HbA1c, TC and LDL-c were well correlated with carotid IMTorresponding correlation coefficient was 0.348、0.206、0.083、0.078、0.125，P 0.05. 3. Multiple logistic analysis shows that age, HbA1c and LDL-c were significant risk factors for carotid atherosclerosis, OR was 1.075、1.123、2.125 respectively, P 0.05. Conclusion In type 2 diabetic patients, age, Blood pressure, HbA1c and LDL-c were closely related to the progress of carotid atherosclerosis in type 2 diabetes. Control of blood pressure, glucose, and LDL-c were crucial to prevent and delay the carotid atherosclerosis in type 2 diabetic patients. 【Key Words】Diabetes mellitus; therosclerosis; Intima-media thickness；metabolic factors. 2型糖尿病的心脑血管并发症是患者致残、致死的主要原因，而动脉粥样硬化是糖尿病心脑血管发病症的病变基础。颈动脉内中膜厚度（Intima-media thickness，IMT）反映动脉结构改变，是动脉粥样硬化过程的早期指标。本研究通过测量颈动脉内中膜厚度评估颈动脉粥样硬化情况，探讨与2型糖尿病患者颈动脉粥样硬化的相关危险因素。为临床预防及延缓2型糖尿病患者