临床（聚酰）TSTD-1生物保存剂对大鼠肝脏低温保存损伤的保护运用.pdfVIP

山西医科大学 硕士学位论文 用 姓名：马海宁 申请学位级别：硕士 专业：外科学 指导教师：鲍民生 摘要 用大鼠肝脏离体非循环灌注低温保存模型，观察各组乳酸林格液中加入不同 作用，在1％的浓度下K值17的作用最强。可能与它在低温时的细胞膜保护 作用和在保存液中可以充当胶体的作用有关，并且与离体低温保存的大鼠肝 脏中肿瘤坏死因子a的减少有关。 关键词 (聚酰)TSTD一1，肝脏， 低温保存， 肿瘤坏死冈子n Abstract To the effectofTSTD—loncold objective studyprotective ofratliver．MethodsWe theeffectsofLactate injury compared solution TSTD·linvarious andmolecularwiththatof including dosage weights RLsolutionadded anisolatednonrecirculatedratliver nothingbyusing perfusion model．Theliverfunctionsinthe solutionandthe of preservation tumornecrosisfactor theratliverwereidentifiedafterCOld o(TNF—a、in The the for12and24hours．Resultsvalueof脚andASTinall preservation TSTD·1 were lowerthanthatinthecontrol groupssignificantly groupfP0．05)． Wealsofoundthe TSTD-lwasbetterthan TSTD-1 1％MKl7 group other groups incold ofratliverfor24 sameconclusioncould preservation hours伊o．05)．The bedrown rat had the ofTNF—ain liveLConclusionTheTSTD-1 by expression all effectonliver Wasthebest I％MKl7 obviouslyprotective pr