糖尿病肾病患者血清趋化因子及氧化应激水平的相关性.docVIP

糖尿病肾病患者血清趋化因子与氧化应激水平的相关性 及α-硫辛酸【摘要】目的 观察血清趋化因子及氧化应激指标在糖尿病肾病（DN）不同时期的α-硫辛酸，探讨趋化因子。方法 选择2型糖尿病患者100例，根据24小时尿白蛋白定量（24h-UAL）水平分为正常组（24h-UAL30mg/24h）、早期DN组（24h-UAL 30~300mg/24h）和临床DN组（24h-UAL300mg/24h），三组患者均给予α-硫辛酸治疗4周，测定各组治疗前后血清趋化因子（FKN、MCP-1）、氧化应激指标（GSH-PX、SOD、MDA）、FPG、2hPG、HbA1C水平及24h-UAL变化。结果 （1）GSH-PX及SOD水平显著高于糖尿病组，血清趋化因子与三组治疗后血清趋化因子与均较治疗前显著下降，GSH-PXSOD水平则显著升高；早期组及临床组治疗后24-UAL较治疗前显著降低；治疗前后临床DN组血清FKN、MCP-1及MDA水平均明显高于正常组和早期DN组GSH-PX及SOD水平则显著低于另两组（P0.05）；（2）趋化因子与、24h-UAL、FPG、2hPG及HbA1C呈正相关，与趋化因子、24h-UAL、FPG、2hPG及HbA1C呈正相关。结论 DN患者血清趋化因子及氧化应激指标水平24h-UAL及血糖水平，抗氧化应激治疗能降低血清趋化因子水平，减少尿蛋白排泄，从而延缓DN的进展。 【关键词】Fractalkine；MCP-1；氧化应激；糖尿病肾病α-硫辛酸he correlation of chemotactic factors and oxidative stress markers in diabetic nephropathy and the effects of α-lipoic acid to them [Abstract] Objectives To observe the differences between serum chemotactic factors and oxidative stress markers in different periods of diabetic nephropathy and the changes of both after therapy ofα-lipoic acid. To explore the correlation of chemotactic factors and oxidative stress markers in diabetic nephropathy and the effects of α-lipoic acid to them. Methods 100 patients with type 2 diabetic mellitus were randomly divided into normal group, early diabetic nephropathy group and clinical diabetic nephropathy group, which were according to 24 hour urinary albumin. Changes of FKN, MCP-1, GSH-PX, SOD, MDA, 24h-UAL, FPG, 2hPG, HbA1C and 24h-UAL before and after treatment of α-lipoic acid for fore weeks in three groups were observed. Another 30 healthy persons were chosen as control group. Results 1. Serum GSH-PX and SOD in control group were obviously higher than other three groups, at the same time, serum chemotactic factors and MDA were lower than diabetic groups. Levels of Serum chemotactic factors and MDA were decreased significantly after treatment in all groups, which of GSH-PX and SOD were in opposite results. 24-UAL was lower than before in normal group and early diabetic nephropathy group. Levels of FKN, M