2011-含莫西与左氧氟方案对耐多药肺结核病观察.docVIP

含莫西沙星方案与含左氧氟沙星方案对耐多药肺结核病的观察 【摘要】 目的 比较和评价含莫西沙星（MXFX）方案与含左氧氟沙星（LVFX）方案联合母牛分枝杆菌菌苗（M.vaccae）对耐多药肺结核病（MDR-PTB）的治疗效果及安全性。方法 将78例痰菌阳性的MDR-PTB患者随机分成试验组（T组）39例与对照组（C组）39例，T组方案：6MDEZA（C）/12MDE、6MDEBTh/12MDE；C组方案：6VDEZA（C）/12MDE、6VDEBTh/12MDE方案。2组患者于治疗期间前6个均加用M.vaccae，疗程结束时可评价疗效者T组33例、C组30例。 结果 治疗满2个月时痰菌阴转率T组为45.45%、C组为20.00%，（P0.05），治疗满4个月时痰菌阴转率T组为57.57%、C组为30.00%，（P0.05）；以后各期痰菌阴转率T组均大于C组，但差异无统计学意义（P0.05）；满疗程时2组病灶吸收好转率分别为66.67%、46.67%，空洞闭合率为分别为17.24%、12.00%，2组对比差异无统计学意义（P0.05）。副作用：T组为30.76%（12/39），C组为38.46%（15/39）两组对比差异无统计学意义（P0.05）。结论 莫西沙星对MDR-PTB的治疗是有效且安全的。【关键词】结核；肺/药物疗法；抗多种药物性 Therapeutic effects of moxifloxacin-containing regimen and levofloxicin-containing regimen in patients on multiple-drug resistant pulmonary tuberculosis WU Shucai，GAO Guanjiu，GENG Shujun，et al. Hebei Provincial Chest Hospital，Shijiazhuang 050041 [Abstract] objective To compare and evaluate the therapeutic efficacy and safety of moxifloxacin-containing regimen and levofloxicin-containing regimen in patients with multiple-drug resistant pulmonary tuberculosis（MDR-PTB）. Methods 70 cases of patients with MDR-PTB that confirmed bacterilogically were divided into one trial group（n=39）and one control group（n=39）randomly. The regimen of the trial group was 6MDEZA（C）12MDE、6MDEBTh/MDE while the other was 6VDEZA（C）/MDE、6DVEBTh/MDE.And all cases were administrated with M.vaccae in the initial 6-month phase as well. The results of bacteriological examination , X ray examination and side effects of the drugs were collected and compared. Results When the trial had been accomplished, 33 cases in trial group and 30 in control group could be used into this study. In full of 2 and 4-months the rates of sputums negative conversion were 45.45% and 57.57% in the trial group and 20.00 %、30.00 in the other（P0.05）, In every phases of the treatment course the full 4-month ,the rates of the sputums negative conversion in trial group were higher than those in the control group, but there were no significant differ