斯康杜尼（scandonest）.docVIP

斯康杜尼（scandonest） Name of drug] Mepivacaine Hydrochloride and Adrenaline Injection Commercial name: J Con Tuni English Name: Mepivacaine, Hydrochloride, and, Adrenaline, Injection Chinese Pinyin: Yansuan, Jiapaikayin/Shenshangxiansu, Zhusheye The main ingredients of this product and its chemical name are: Hydrochloride (Mepivacaine hydrochloride) - - - - 20.00mg/ml Adrenaline (Adrenaline) - - - - - - - - 0.01mg/ml Its structural formula is: Molecular formula: hydrochloride, ropivacaine, C15H23ClN2O, epinephrine, C9H13NO3 Molecular weight: tetracaine hydrochloride, 282.8 epinephrine, 183.2 [traits] This product is colorless transparent liquid [pharmacology, toxicology] Pharmacological action: Ropivacaine hydrochloride is a new kind of amino local anesthetic. It acts on sensory and motor nerve fibers, which is effective and effective for long periods of time and can effectively block nerve conduction. The addition of epinephrine to the anesthetic can slow down the speed of the operation of tetracaine hydrochloride in the body, thereby ensuring the time and effect of anesthesia and reducing the dosage to some extent. Toxicological studies: The lethal dose of ropivacaine hydrochloride to human body is 5~10 mu g/ml, which is less toxic compared with lidocaine and procaine. There is no animal experimental data to determine its carcinogenicity, mutagenicity, and reproductive toxicity. There is no information about the human being, indicating that the product may be carcinogenic, mutagenic, and reproductive toxicity. [pharmacokinetics] As a peripheral nerve block, the effect of tetracaine hydrochloride began 2~4 minutes after injection. Its distribution rate in vivo was 0.8, and the binding rate with plasma protein was 60~78% (mainly with oxygen glycoprotein), and its pKa value was 7.6. Usually, the half-life of 600mg hydrochloride in plasma is 2~3 hours, while for liver disease and diabetes patients, the half-life will be prolonged. The metabolism of ropivacaine hydrochlori