antipsychotic drugs classification： phenothiazin 吩噻嗪类.pptVIP

Antipsychotic drugs Schizophrenia 精神分裂症 literal translation “split mind” separate emotional side from intellectual side emotional cognitive processes dont function together a group of severe disorders characterized by: disorganized and delusional thinking（妄想） disturbed perceptions inappropriate emotions action Psychotropic Drugs 抗精神失常药 Classification： antipsychotic drugs 抗精神病药物 neurotropic drugs 神经安定剂 antimanic drugs 抗躁狂药物 antidepressants 抗抑郁药物 anxiolytics 抗焦虑药物 Nature of psychosis /schizophrenia The dopamine hypothesis excessive dopaminergic activity plays a role in the disorder. The enhancement of function of 5-HT2 Dopaminergic Systems The nigrostriatal pathway (coordination of voluntary movement ) Mesolimbic- mesocortical ( behavior ) Tuberoinfundibular- pituitary system (endocrine) The medulla oblongata (vomit) Medullary - periventricular pathway ( eating behavior) Antipsychotic drugs Classification： Phenothiazin 吩噻嗪类 (氯丙嗪 chloropromazine ) Thioxanthenes 硫杂蒽类 (chlorprothixene 氯普噻吨（泰尔登）) Butyrophenones 丁酰苯类 (haloperidol 氟哌啶醇) Others neuroleptic effect (神经安定作用) powerful antiemetic action 镇吐作用 blocking CTZ 催吐化学感受区 D2-R (small dosage) directly inhibiting vomiting center 呕吐中枢 (large dosage) altering temperature-regulating mechanisms decrease temperature no matter normal or high temperature body temperature varies with the environment Therapeutic uses schizophrenia 精神分裂症 more effective in treating positive symptoms severe nausea and vomiting useful in the treatment of drug-induced nausea hypothermic anesthesia 低温麻醉 and artificial hibernation 人工冬眠 chlorpromazine – promethazine – pethidine （氯丙嗪 – 异丙嗪 – 哌替啶） Thioxanthenes 硫杂蒽类 chlorprothixene 氯普噻吨（泰尔登） Butyrophenones 丁酰苯类 haloperidol 氟哌啶醇 Others penfluridol 五氟利多 clozapine 氯氮平 Clozapine (氯氮平) Benzodiazepines Pharmacological effect Blocking 5-HT, D2 receptor Strong efficac