个体化组织工程骨治疗骨纤维异常增殖症的临床 - 第三军医大学学报.doc

个体化组织工程骨与同种异体骨修复骨纤维异常增殖症术后骨缺损的对比研究 吴治林，侯天勇，刘 杰，王序全，许建中 （400038重庆，第三军医大学西南医院骨科，全军矫形外科中心，组织工程国家地方联合工程实验室，重庆市再生重建医学工程技术研究中心，重庆市组织工程实验室） [摘要] 目的 对比分析组织工程骨修复骨纤维异常增殖症术后骨缺损的长期临床疗效。方法 回顾性分析10例个体化组织工程骨病例（组织工程骨组）和10例同种异体骨病例（异体骨组）移植修复重建骨纤维异常增殖症刮除术后骨缺损的临床资料。比较两种方法的愈合时间、骨性愈合评分、并发症发生率及植骨失败率，评价组织工程骨治疗骨纤维异常增殖症的临床疗效。结果 组织工程骨组10例平均随访（63.6±19.6）个月，患者1 例术后2年出现病理骨折再次手术，其余9 例患者术后骨缺损获得良好修复，愈合时间（3.3±1.6）个月，骨性愈合评分（2.6±0.5）分。异体骨组10 例随访（55.1±15.4）个月，1例术后2年出现复发，3 例出现骨移植区疼痛、局部肿胀等并发症，骨缺损均获得良好修复，愈合时间（6.0±2.4）个月，骨性愈合评分（2.4±0.8）分。两组之间在并发症发生率以及愈合评分方面的差异无统计学意义（P ＞0.05）；在愈合时间方面的差异有统计学意义（P＜0.05）。结论 个体化组织工程骨在治疗骨纤维异常增殖症能获得优于同种异体骨的疗效且具有较高的生物安全性，是治疗骨纤维异常增殖症的一种新选择。 [关键词] 组织工程骨；骨纤维异常增殖症；同种异体骨；骨移植 [中图法分类号] [文献标志码] A A comparative study on epairing bone defect of fibrous dysplasia using Individualized tissue engineering bone and allograft Wu Zhilin，Hou Tianyong，Liu Jie，Wang Xuquan，Xu Jianzhong（National Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, the Third Military Medical University, Chongqing, China；National and Regional United Engineering laboratory of Tissue Engineering；Center of Regenetive and Reconstructive Engineering Technology in Chongqing City, Chongqing, China；Laboratory of Tissue Engineering, Chongqing City, Chongqing, China.) [Abstract] Objective To the clinical efficacy and biosafety of individualized tissue engineered bone in repairing bone defect of fibrous dysplasia compare with allograft. Methods A retrospective analysis was performed in 20 patients with bone defects cause by fibrous dysplasia who underwent bone reconstruction, with the use of tissue engineered bone in 10 patients，and the other 10 patients use the allograft. The healing time, bone healing score (according to Jorgenson standard), incidence rate of complications in two groups were compared with each other. Results In bone tissue engineered bone group, the average duration of follow-up 63.6±19.6 months. 1 patien