壳聚糖与知母配伍对糖尿病小鼠晚期糖化终末产物的影响-食品科学.PDF

※营养卫生 食品科学 2007, Vol. 28, No. 0 553 1 1 2 2 葛喜珍 ，林 强 ，张 静 ，王 鑫 (1.北京联合大学生物化学工程学院，北京 100023；2.北京化工大学生命科学与技术学院，北京 100029) ：目的：探讨壳聚糖及其与知母配伍对糖尿病小鼠晚期糖化终末产物的抑制和降糖作用。方法：四氧嘧 啶腹腔注射建立糖尿病小鼠模型，将小鼠分为正常组(normal)、模型组(model)、壳聚糖组、壳聚糖+知母组(高、 低)，连续灌胃 28d，取血清测定生化指标。结果：与正常组相比，模型组血糖、果糖胺、游离脂肪酸、晚期 糖化终末产物(AGEs)、MDA 明显升高，pH、SOD 明显降低。与模型组相比，壳聚糖组MDA、血糖和AGEs 明显降低，SOD 明显升高；壳聚糖+ 知母高剂量组MDA 显著降低，血糖和AGEs 明显降低，SOD 明显升高； 各组pH 值明显升高。结论：壳聚糖及其与知母配伍对糖尿病小鼠有保护作用。 ：壳聚糖；知母；晚期糖化终末产物；血糖；果糖胺 Effects of Chitosan and Its Rhizoma anemarrhenae Mixture on Advanced Glycosylation End Products( AGEs) of Diabetic Mice 1 1 2 2 GE Xi-zhen ，LIN Qiang ，ZHANG Jing ，WANG Xin (1. College of Biochemical Engineering, Beijing Union University, Beijing 100023, China； 2. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China) Rhizoma anemarrhenae mixture on regulating Abstract ：Objective: The purpose was to evaluate the efficacy of chitosan and its blood glucose and advanced glycosylation end products( AGEs) in diabetic mice bodies. Method: Diabetes mellitus model was established by intraeritoneal injecting of alloxan, and the mice were randomly divided into normal group, model group, chitosan Rhizoma anemarrhenae group(high and low). The mice were treated with drugs intragastrically(ig) for 28 days, group, chitosan + the following parameters were evaluated: serum glucose,