载药纳米颗粒在微血管内靶向输运过程格子boltzmann模拟 牛永健.docVIP

中国工程热物理学会 传热传质学 学术会议论文 编号：143702 载药纳米颗粒在微血管内靶向输运过程格子boltzmann模拟 牛永健, 乐恺*, 张欣欣 (北京科技大学机械工程学院热能工程系 100083) (Tel Email:ustb_niu@163.com) 摘要：纳米颗粒作为药物输运的载体，其在微血管内的输运以及在血管壁的附着对药物输送的研究至关重要。本文对载药纳米颗粒在微血管内的靶向输运过程进行了分析，血液流动和颗粒在微血管内的运动结果表明，计算结果对纳米颗粒靶向输送药物的临床或实验研究有一定的参考价值 关键词：格子boltzmann；格子气自动机纳米颗粒；靶向输运 Ttargeting transport of drug loaded nanoparticles in microvascular by lattice boltzmann method Abstract: Studying the transport and binding of nanoparticle in micro vessel has significant value on drug delivery system. We make a deep analysis on the targeting transport process of drug loaded nanoparticles in micro vessel, and establish the mathematical physical model of particle transport and distribution in consideration of the effect of flow resistance, brown force and particle adhesion. We simulate the blood flow and particle motion in micro vessel by lattice boltzmann and lattice gas automata method. It is ignored that the effect of gravity, buoyancy, van der waals force and electrostatic force of nanoparticle which the diameter is under 200nm. The simulation results show that more nanoparticles will attach to the vessel wall with larger concentration of nanoparticle suspension, smaller particle diameter, smaller vessel diameter and smaller blood viscosity. We hope the results have a certain reference value for clinical or experimental study on targeting system of drug loaded nanoparticle. Key words: lattice boltzmann method; lattice gas automata; nanoparticle; targeting transportation 1 引言 当今肿瘤的主要治疗方法是放疗和化疗，全身性的治疗，在消灭肿瘤细胞的同时，也会对人体健康造成损伤。使用纳米颗粒装载药物，通过控制颗粒的运动，使靶向输送到肿瘤，既提高药物利用率，也健康组织。颗粒靶向输送药物治疗肿瘤在近年得到了广泛的关注与发展。 学者对纳米颗粒靶向输送药物进行了理论和实验研究。Maeda等[1]研究发现，由于肿瘤组织的EPR(enhanced permeability and retention)作用，载药颗粒可以通过被动靶向输运的方式渗透通过血管壁，进入肿瘤组织。Davis等[]在临床中使用纳米颗粒靶向输送siRNA用于基因治疗。Hrkach等[]在临床中使用纳米颗粒靶向输送抗肿瘤药物治疗癌症。方面， Tan[]等模拟了纳米颗粒在血管内的输运与分布，考虑了颗粒的布朗运动与修饰后的颗粒与靶区壁面