健康成人吞咽口腔期的功能磁共振成像研究.pdf

2013 年，第28 卷，第9 期 ·临床研究· 健康成人吞咽口腔期的功能磁共振成像研究 1 1，4 1 2 2 3 吴军发 胡永善 吴 毅 施爱萍 路微波 刘含秋 摘要 目的：探讨健康成人吞咽口腔期的神经控制机制。 方法：通过血氧水平依赖性磁共振脑功能成像(BOLD-fMRI) 技术，研究8位健康志愿者叩齿和和舌尖沿上腭由前向 后滑动时脑激活情况，用SPM5图像处理软件处理功能磁共振成像资料。 结果：叩齿时，激活区主要分布于双侧中央前回、邻近的双侧岛盖、双侧辅助运动区；舌尖沿上腭由前向后滑动时，激 活区主要分布在双侧中央前回、邻近的双侧岛盖、双侧辅助运动区、双侧小脑后叶结节、双侧小脑后叶下半月小叶。 叩齿和舌尖沿上腭由前向后滑动共同激活区位于双侧的中央前回、邻近的双侧岛盖和双侧辅助运动区。 结论:双侧的中央前回、邻近的双侧岛盖及双侧的辅助运动区是吞咽口腔期的神经控制网络的一部分。 关键词 叩齿；舌尖运动；吞咽障碍；功能磁共振成像 中图分类号：R49 文献标识码：A 文章编号：1001-1242（2013）-09-0789-05 A functional magnetic resonance imaging study of oral phase of swallowing in healthy humans/WU Jun⁃ fa, HU Yongshan, WU Yi,et al.//Chinese Journal of Rehabilitation Medicine ，2013 ，28(9): 789—793 Abstract Objective:To explore the neurophysiology mechanism of oral phase of swallowing in healthy humans. Method ：During eight healthy volunteers were knocking their teeth and moving the tongue tip backwards along the palate, the activation pattern of cortex was showed with blood oxygen level dependent-functional magnetic resonance imaging(BOLD-fMRI).Image data were analysed by microsoft SPM5. Result ：When subjects were knocking the teeth,bilateral precentral gyruses,adjacent rolandic operculums (ROs) and supplementary motor areas(SMAs) were significantly activated. When subjects were moving the tongue tip backwards along the palate,significant activations were observed in bilateral precentral gyruses, adjacent ROs and SMAs,cerebellum tuber and cerebellum inferior semi-lunar lobule. The common activated areas during knocking the teeth and moving the