姜黄素金属配合物的合成表征和抗肿瘤活性研究.pdfVIP

Chinese Journal ofNew Drugs 2008, Vol. 17N o. 19 2008 17 19 , , , (福建医科大学药学院, 福州 350004) [] : 合成和表征 了 4个姜黄素的金属配合物, 并对其抗肿瘤活 进行初步的研究 : 以姜黄素为配体合成其乙酰丙酮氧钒锌铜锡的配合物, 用红外光谱紫外光谱元素分析对配合 物进行了表征, 并进行体外抗肿瘤活 初步筛选: 合成了4个姜黄素的金属配合物, 并确定其结 构: 药理活 筛选结果表明, 多个配合物对肿瘤 K562, HL60细胞有效, 部分配合物显示了较强的 抗癌活 [] 姜黄素; 配合物; 抗肿瘤活 [] R979. 1; R914. 5 [] A [] 1003- 3734( 2008) 19- 1676- 03 Synthesis, characterization and in vitro antitumor activity of curcum in complexes CHEN Lim in, LI Yang, LI Guangwen, LINa (Faculty of P harm acy, F uj ian M ed ical Un iv ers ity, Fuz hou 350004, Ch ina ) [Abstract] Objective: To synthesize and characterize four complexes of curcum in, and to investigate the antitumor activity of these complexes. M ethods: The complexeswere prepared using curcum in as a ligand. These complexeswere characterized by IR spectra, V spectra and elemental analyses, and their antitumor activitywas determ ined in in v itro models. Results: Four new complexes were synthesized and their structures were deter m ined. The complexes showed antitumor activity in K562 andHL60 tumor cells in v itro. onclusion: Curcum in complexes have been synthesized and characterized; they have antitumor activities. [Keywords] curcum in; complex; antitumor activity (Curcum a long a L. ), 1870 ( curcum in, 1 Cur), 1910 Lampe, AVATR 330 FTIR, KBr, 752PC, Vario EL , [ 1] , JYAR , 2 [4] , 2. 1