基于5-芳基乙内酰脲类化合物的CoMFA和HQSAR研究.pdfVIP

!#$$% ! !#$ %’( )(*+ ! ’ #$% , -. /0123 450$63 7$8 ’ ( !# ! #% #$% ) #$#% *+,-./0 ! $% #!$%’()*+, ’()* - +,-*. ./ ! ! #$% ’( )*+ , - ./0 !?@A$BCD$E( FGHIJKLDMNOPQRS( BC 2#4#% 01 T H-IJK U LMNKO VW MNKO XYZ[\ 4% ]^_‘abFGcdefgh/ ’ iZ[jfklm nocpqrfstf2#u!FGcfk ( 2v H-IJK wx( yz{\|}~lm ’ LMNKO i!#$W % c MNKO XY( J H-IJK XY’(( )XY*+,-X.( ( H-IJK XY/0( y12O345 ’ VW XY6o)\75F8r9( H-IJK c:;R’h/+ 9$ = %’ F #4( LMNKO c 9$ = %’ FG2’ ?@XM ABCDE \)bFG* !O( O 1 :12( 41A9B9,0-./B=-P:1#( $1A9879B/ xF4Gd’HFIM JcKLMN( O PQbRHFcQRZ[ST \UVW ’ 2345 (7FGBXF8Y( |Y MNKO( FZMG( F4[\ 567(85 *3# v]^f] ~c_g‘ya’b( cc$W gu1S\ChT)FGHIcZ[L J Q# 1#F R ( h ^f] cd TefghOi] ’ *jklom$ r92JhiMN $U1MNKO( H-IJK U (7FG no4#u!cXY J( p’qrFZY#$Ws bR4F8 !H-INYK +XYnor9jk ’ Z90S:/ tuvwgcXY Q # R ’ x$X.( OF4[\y +0 QF R }F4qrlZ[Fm( jQRcno s cz{ \|2}~ !|F4[\ t# c$ t( Og 41 p9^_‘ab#u!* !2O( N 1 %h’(cKLMN Q$ R ( ?Og_!)B$Z[ [X/:S1*1: xqrl cFZyz{\qr ( s }_ !FGHIU* cF4Gd ’ cHI+X #h gtb#u!F ZycUZ[ uvw% .,A-O( c./ Q2 R ’ 0TI1y234Z[F x ’ iyjU cno st( O Z90S:/ DdzHF 4[\ cy( 5g0OF4[\IMc|U c 4% ] 41 p 9^_‘aFGz{\ H-IJK U 6[( n }7478)O9 Q R ’ :;4( -k c8$ LMNKO Z[ ( jFGwxno{| \hF4HF DdT2wcXYo)\=. cr9 Q41G R 5 $%%# y ’ ; N=S9 +0 Q#% R0T I89/0 cQRFZMG :T ! Q## R z{c $U1MNKO U (7FGXF8 !H-IJK Z / ’()* 9:;7 [( IO ?4Uv]@+ cABF8( o)\7 /0 / =?,@ABCD7E,FGH7EI* 5 cF8r9( xC( V9WS-9,= +0 Q#$ R DEde pqfklmDdT \9-H8+X/ }~!S !4% fgh/Z[‘T)\[\F cFGGH J ’ I, ]^_‘aFGcrfUQR+,w# # ’ $] U8:T:/9@X Q#2 R S scEP’JdTwKU( nAF