青藤碱治疗类风湿性关节炎抑制骨破坏的研究进展.PDF

2011 1 27 1 98 JOURNA L OF NANJING TCM UNI VERSITY Vol. 27 No. 1Jan. 2011 * 1* 2 1 1 1 1 1 丁从珠 , 汪悦 , 姚瑶 , 方芸 , 赵成, 冯学兵 , 孙凌云 ( 1. , 210008; 2. , 210046) :类风湿性关节炎( rheumat oid arthritis, RA) 骨质侵蚀与关节破坏 近年来研究的热点破骨细胞 导致关节侵蚀 的主要细胞将近几年青藤碱( sinomenine, SIN) 在类风湿性关节炎骨破坏的调控机制予以综述, 以期进一步研究SIN 对RA 破骨细胞的作用机制 :类风湿性关节炎; 青藤碱;骨破坏 : R285 : A : 1000 5005(2011) 01 0098 03 Study on Sinomenine in Treating Rheumatoid Arthritis and Inhibiting Osteoclasia DIN G Cong-z hu1* , WAN G Yue2 , YA O Yao 1 ,FAN G Yun 1 ZHA O Cheng 1 ,FEN G Xue-b ing 1 ,S UN L ing-y un 1 (1.Drum T ower Medical College of Chinese and Western Integ rative Medicine, Nanj ing University of Chinese Medi cine, Nanj ing , 210008;2 .The First Medical College, N anj ing University of Chinese Med icine, Nanj ing , 210046,China) ABSTRACT: Osseous erosion and art icular destruction in rheumatoid arthritis ( RA) have become research hotspots in re cent years. Osteoclasts are main cells resulting in articular erosion. The regulatory mechanism of sinomenine ( SIN) in rheumatoid arthritis osteoclasia in recent years is researched in the paper to further st udy the mechanism of SIN on RA os teoclasts. KEY WORDS: rheumat oid arthritis; sinomenine; osteoclasia (Rheumatoid arthritis, RA) , , , RA , RA , SIN IL , 1T NF mRNA NF B , IL 10 ( sinomenine