阿托伐他汀对充血性心力衰竭患者炎症反应的干预作用.pdfVIP

Med＆ Pharm．Vol 25．2008一O6 N 临床研究 阿托伐他汀对充血 心力衰竭患者 · 论 著· 炎症反应的干预作用 - t-冠鹏 李春生 魏运亮 (152医院心血管内科，河南平顶山 467000) f摘 要] 目的 观察阿托伐他汀充血性心力衰竭患者血清炎性细胞因子变化以及短期干预作用。方法 将46例血浆胆固醇正常(22mg／m1)的心力衰竭患者随机分为两组。常规治疗组，常规抗心衰治疗；阿 托伐他汀组，常规抗心衰治疗基础上给予阿托伐他汀lOmg／d。于治疗4周后采用ELISA法测定血浆肿瘤 坏死因子一 (NF— )、白细胞介素一6(IL一6)、可溶性血管细胞粘附因子一1(sVCAM-1)。结果 于治疗4周 后，阿托伐他汀组血浆中TNF—d、IL．6、sVCAM一1明显低于常规治疗组( O．叭)。结论 阿托伐他汀可以 降低血清胆固醇正常的充血性心力衰竭患者的机体炎症反应。 【关键词】阿托伐他汀 炎症反应 充血性心力衰竭 【中图分类号】R541．6：R972．6 【文献标识码】A Effects of atorvastatin on inflammatory process in patients with congestive heart failure FENG Guan-peng，LI CHun—sheng，WEI Yun—liang．Department of Cardiology，No．152 Central Hospital of PLA， Pingdingshan 467000，China 【Abstract】 Objective To investigate short—term treatment effects of atorvastatin on inflammatory process in patients with congestive heart failure(HF)and normal cholesterol levels．Methods The effect of 4-week atorvastatin treatment (10 mg／day)on inflammatory markers in patients with HF and cholesterol levels220 mg／dl was investigated．Forty—six patients were randomly allocated into two groups：routine group received traditional treatmeng and atorvastatin group received atorvastatin (23 cases each group)．Serum levels of tumor necrosis factor alpha (TNF—0【)，interleukin 6 (IL-6)，and soluble vascular cell adhesion molecule (sVCAM-1)were determined with EL1SA．Results Levels of 1L-6， TNF-et and sVCAM-1 were decreased in atorvastatin group but not in the routine group．Conclusion Atorvastatin may depress inflammatory process in patients with heart failure and normal baseline eholesterol levels． 【Key words] Atorvastatin Inflammation Congestive heart failure 充血性心力衰竭(CHF)是以左室功能降低、运 1．1 研究对象 选择慢性充血性心力衰竭住院患 动能力减弱为特征。伴随着神经内分