胡萝卜素单独或合并使用维生素E.PDFVIP

Nutr Sci J, 2012, Vol. 37, No. 1, pp.1~13 視網酸和 -胡蘿蔔素的抗發炎效應 1 視網酸和 -胡蘿蔔素單獨或合併使用維生素 E 對 LPS 誘發的發炎反應的影響：體外研 陳珮瑩1 鄭妃吟2 葉姝蘭1,2* Effects of retinoic acid and -carotene alone or in combination with -tocopherol on LPS-induced inflammation: an in vitro study 1 2 1,2* Pei-Ying Chen , Fei-Yin Jheng , Shu-Lan Yeh 1Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan. 2 Department of Nutritional Science, Chung Shan Medical University, Taichung 40201, Taiwan. ABSTRACT The aim of this study was to compare the effects of 2 M retinoic acid RA and （ ） -carotene BC alone or in combination with 10 M -tocopherol on the secretion of pro- and anti- （ ） inflammatory cytokines as well as the production of reactive oxygen species ROS in RAW264.7 （ ） cells induced by lipopolysaccharide LPS . In addition, we compared the toxicity of conditioned media （ ） toward C3H10T1/2 cells. RA alone significantly decreased the secretion of tumor necrosis factor TNF - and intracellular ROS levels in RAW264.7 cells induced by LPS, but had no effect on the （ ） secretion of interleukin IL -6 or IL-10. RA in combination with BC significantly decreased the sec-