蠲逆清中饮治疗脾胃湿热型反流性食管炎的临床探究.pdfVIP

提 要 目的：观察蠲逆清中饮治疗脾胃湿热型反流性食管炎 (reflux esophagitis， RE)的临床疗效，并从理论和临床研究两个方面探讨蠲逆清中饮治疗 RE 的机制。方 法：临床选择符合纳入标准的 RE 患者 60 例，随机分为两组，治疗组（30 例）给予 蠲逆清中饮水煎剂，对照组（30 例）给予胃力康颗粒（四川宝光药业股份有限公司 生产），观察两组的临床疗效。结果：临床研究显示，治疗组治愈 9 例，显效 16 例， 有效 4 例，愈显率（痊愈+显效率）为 83.33 ％，总有效率为96.67 ％。对照组临床痊 愈 4 例，显效 4 例，有效 14 例，愈显率为 26.67 ％，总有效率为73.33 ％。治疗组胃 镜疗效总有效率 96.67 ％，对照组为 73.33 ％。治疗组显著优于对照组（愈显率比较 P0.01 ，总有效率比较P0.05 ，胃镜疗效总有效率比较P0.05 ）。治疗组在胃镜疗效 积分与中医证侯总积分和消除或改善泛酸、烧心、胸膈满闷、胸痛、纳差以及口苦口 粘和嗳气等症状上，疗效优于对照组。结论：蠲逆清中饮是治疗脾胃湿热型 RE 的有 效方剂，其机理可能与调节胃食管运动，改善食管下括约肌功能，以及对胃肠激素的 调节和抗炎作用等有关。 关键词 蠲逆清中饮；反流性食管炎 (reflux esophagitis，RE)；脾胃湿热； 临床研究 Clinical Study of Treating reflux esophagitis With Juan Ni Qing Zhong Yin Specialty:Gastroenterology Internal Medicine of TCM Author:Wang Jianbo Tutor:Professor Lu Guangchao Abstract Objectiv :To observe the clinical curative effect of Juan Ni Qing Zhong Yin on reflux esophagitis of Damp Heat in Spleen and Stomach and explore the mechanism of which from theoretical and clinical aspects ．Methods:60 cases with reflux esophagitis were divided into two groups at random:the treatment group (30 cases)and the control group (30cases) ．The former was given Juan Ni Qing Zhong Yin while the latter was given Wei Li Kang Ke Li ．Symptoms and signs of each group were observed before and after the treatment,including gastroscope observing ．Results:After one course of treatment,significant difference was apparent in the clinical effects;In the treatment group,9 cases recovered and 16 cases significantly improved,(thus the effectual rate is 83.33%),4 cases improved. The total effective rate in the trea