血流感染病.ppt

血流感染病原学诊断进展 任健康 陕西省人民医院 陕西省临床检验中心 Outline The need of physisians in case of sepsis Timely reprot of etiologial diagnosis vs clinical outcome The characterastics of future etiological dianostic technologies Bacteremia Being categorized as transient, intermittent, or continuous bacteremia. The microbial load may be as low as 1 CFU/ml. Bacteremia and sepsis Bacteremia may be associated with the development of sepsis, if not properly controlled. Sepsis is a clinical syndrome related to an infectious process with important alterations in the inflammatory response and coagulation. Sepsis TABLE 1. Definitions for sepsis and organ failure Syndrome Definition Systemic inflammatory response syndrome ............2 of the following signs and symptoms: WBC count of ＞12,000 cells /mm3 or ＜4,000 cells/mm3 or ＞ 10% immature forms; body temp of ＞ 38°C (100.4°F) or ＜ 36°C (96.8°F); pulse of ＞ 90 beats per min; respiratory rate of ＞ 20 breaths per min; or PaCO2 of 32 mm Hg Sepsis .....................................................................SIRS due to suspected or confirmed infection Severe sepsis .........................................................Sepsis complicated by organ dysfunction, hypoperfusion, or hypotension Septic shock ...............