蜂胶(翻译.doc

天然产物巴西蜂胶加强吞噬细胞杀真菌的活性 Abstract Natural product incorporation into microcarriers increases the bioavailability of these compounds, consequently improving their therapeutic properties. Natural products, particularly those from bees such as propolis, are widely used in popular medicine. Propolis is a powerful treatment for several diseases. In this context, the present study evaluated the e?ect of propolis Scaptotrigona sp. and its fractions, alone or adsorbed to polyethylene glycol (PEG) microspheres, on the activity of human phagocytes against Candida albicans.The results show that propolis exerts a stimulatory e?ect on these cells to assist in combating the fungus, especially as the crude extract is compared with the fractions. However, when incorporated into microspheres, these properties were significantly potentiated. These results suggest that propolis adsorbed onto PEG microspheres has immunostimulatory e?ects on phagocytes in human blood. Therefore, propolis may potentially be an additional natural product that can be used for a variety of therapies. 天然产物包埋在载体中能够增加这些化合物的生物药效，因此能够提高它们的治疗功效。天然产物，特别是些来自蜜蜂的，例如蜂胶，正被广泛的应用到流行药中。对于一些疾病，蜂胶具有非常好的治疗功效。鉴于此，现在研究评估Scaptotrigona sp.的蜂胶及其馏分在单独的或吸附到聚乙二醇微粒上时，对人类吞噬细胞作用白色念珠菌的效果。结果表明蜂胶对这些细胞对抗真菌具有辅助的促进作用，值得注意的是粗提物的效果要比馏分的促进效果更好。但是包埋到PEG微粒中的蜂胶的这些功效要更强。这些结果表明：吸附到PEG微粒上的蜂胶在人类血液中对吞噬细胞具有免疫调节功效。因此，蜂胶有可能作为一种天然产物添加，用在各种各样的治疗中。 前言 The current focus on natural products and alternative medicines has renewed interest in bee products such as honey, royal jelly, pollen, and propolis. Propolis is a sticky dark-coloured material collected by worker bees from the leaf buds or exuded from numerous tree species. Once collected, this material is enriched with salivary and enzy-matic secretions and used in the construction, adaptation, and protection of their nests [3,4]. In this way propolis chemical composition is a direct reflex of the vegetable flora and bee species [5,6]. 目前关于天然产物和可替代性药品的研究又重新集中于像蜂蜜、蜂王浆、花粉、蜂胶等蜜蜂产品上，蜂王浆是一种黑色粘稠的物质，是由雄蜂采集自叶芽或许多树种的渗出液。