脊柱结核c.pptVIP

1、Monocyte Chemotactic Protein-1 -2518 Gene Polymorphism and Susceptibility to Spinal Tuberculosis单核细胞趋化蛋白-1-2518的基因多态性与脊柱结核的敏感性。2、Enzyme-linked immunospot assay response to recombinant CFP-10/ESAT-6 fusion protein among patients with spinal tuberculosis: implications for diagnosis and monitoring of surgical therapy酶联免疫斑点技术对脊柱结核患者中重组CFP-10/ESAT-6 融合蛋白的反应性：诊断与外科手术治疗监测的意义。 1、Monocyte Chemotactic Protein-1 -2518 Gene Polymorphism and Susceptibility to Spinal Tuberculosis 单核细胞趋化蛋白-1-2518的基因多态性与脊柱结核的敏感性。 （Department of Spine Surgery, Xiangya Hospital, Central South University, Hunan, China Clinical Laboratory, Secondary Affiliated Hospital, Fujian Medical University, Fujian, China） Archives of Medical Research 45 (2014) Background and Aims. Monocyte chemotactic protein-1 (MCP-1) gene polymorphisms play important roles in regulating immunological reactions and may be associated with pulmonary tuberculosis. However, the relationship between the MCP-1 -2518 gene polymorphism and susceptibility to spinal tuberculosis remains unknown. 背景与目的 单核细胞趋化蛋白-1（MCP-1）基因多态性在调节免疫反应中发挥重要作用，可能与肺结核的发生密切相关。然而，在MCP-1-2518基因多态性与其对脊柱结核敏感性之间的关系尚不清楚。 We undertook this study to investigate the relationships between MCP-1 promoter 2518 genotype frequency and allele polymorphisms and susceptibility to spinal tuberculosis in a Chinese Han population. 本研究旨在探讨中国汉族人群中MCP-1基因启动子2518基因型频率和等位基因多态性与脊柱结核易感性的关系。 Methods. Patients with spinal tuberculosis and healthy volunteers were enrolled between December 2004 and December 2010. MCP-1 -2518 polymorphisms in both groups were detected using polymerase chain reaction and DNA sequencing. MCP-1 genotype was analyzed in all patients. Differences in genotype frequencies between groups were compared using χ2tests. 方法： 选取2004年12月至2010年12之间的脊柱结核病人和 健康志愿者纳入到本研究中。两组均采用聚合酶链反应和DNA序列测定来检测MCP-1 -2518 基因多态性，所有患者的MCP-1基因型均进行了分析。采用χ2检验来比较组间基因型频率差异。 Results. A total of 208 patients with spinal tuberculosis and 21